Thymic stromal lymphopoietin ligand
Webb9 sep. 2016 · These epithelial cell‐derived cytokines, which include IL‐25, IL‐33, and thymic stromal lymphopoietin, assist in activating the adaptive Th2 cascade, as well as stimulating basophils, mast cells, eosinophils, and type 2 innate lymphoid cells (ILC2s). 17 Increased populations of ILC2s have been observed in CRSwNP versus CRSsNP. WebbThymic stromal lymphopoietin is an epithelial cell-derived cytokine expressed in gut, lungs, skin, and thymus. It affects both the local dermal dendritic cells ... found that TSLP synergized with CD40 ligand to promote DC activation and pathogenic IL-23 production by primary blood and skin DCs.
Thymic stromal lymphopoietin ligand
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Webb1 nov. 2014 · Thymic stromal lymphopoietin (TSLP) is a member of the four-helix bundle cytokine family and a distant paralog of IL-7 ( 1 ). As the name suggests, TSLP was first identified as an activity in the supernatants of a mouse thymic stromal cell line that was capable of supporting immature B cell proliferation and development ( 2 – 4 ). Webb29 jan. 2016 · These thymic stromal cells coordinate a three-dimensional meshwork architecture that hosts hematopoietic stem cell-derived T-lineage cells, called thymocytes, and critically supports their development. The thymus is subdivided into two histologically discrete regions, the cortex and medulla.
Webb14 apr. 2024 · The alarmin cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) play a critical role in asthma pathogenesis by inducing mucosal Th2-type cytokine production. Webb1 jan. 2024 · Thymic stromal lymphopoietin (TSLP), positioned at the top of the inflammatory cascade, is a key regulator that enhances allergic inflammatory responses by activating T helper type 2 cells, Group 2 innate lymphoid cells (ILC2), and myeloid dendritic cells (mDCs) via the TSLP receptor (TSLPR). We evaluated the inhibitory effects of …
Thymic stromal lymphopoietin (TSLP) is a protein belonging to the cytokine family. It is known to play an important role in the maturation of T cell populations through activation of antigen-presenting cells. TSLP is produced mainly by non-hematopoietic cells such as fibroblasts, epithelial cells and different types of … Visa mer TSLP production has been observed in various species, including humans and mice. In humans TSLP is encoded by the TSLP gene. Alternative splicing of this gene results in two transcript variants. Visa mer It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of myeloid (CD11c ) dendritic cells. TSLP … Visa mer The TSLP signaling axis is an attractive therapeutic target. Amgen's Tezepelumab, a monoclonal antibody which blocks TSLP, is currently approved … Visa mer • Overview of all the structural information available in the PDB for UniProt: Q969D9 (Thymic stromal lymphopoietin) at the PDBe-KB. Visa mer TSLP expression is linked to many disease states including asthma, inflammatory arthritis, atopic dermatitis, eczema, eosinophilic esophagitis and other allergic states. The factors … Visa mer • Ziegler SF, Liu YJ (July 2006). "Thymic stromal lymphopoietin in normal and pathogenic T cell development and function". Nature Immunology. 7 (7): 709–14. doi:10.1038/ni1360. PMID 16785889. S2CID 26635282. • Liu YJ (August 2007). Visa mer Webb1 dec. 2011 · Among these genes, the interferon-gamma-inducible protein 30 (IFI30), CD163 molecule (CD163), chemokine (C-X-C motif) ligand 9 (CXCL9) and thymic stromal lymphopoietin (TSLP), were selected for further genetic analyses.
Webb1 aug. 2006 · We have demonstrated that cytokine thymic stromal lymphopoietin (TSLP), whose expression is rapidly induced upon keratinocyte-selective ablation of retinoid X receptors (RXRs) -α and -β in the mouse (RXRαβ ep−/− mice), plays a key role in initiating a skin and systemic atopic dermatitis-like phenotype. We show here that topical …
Webb18 juli 2007 · Thymic stromal derived lymphopoietin (TSLP) is preferentially and highly expressed in the thymus, but its function in T cell development is not clear. We report here that TSLP, independently or in combination with IL-7, enhances thymopoiesis in the murine fetal thymic organ culture (FTOC) model. Furthermore, TSLP preferentially increases the … humbert mauriceWebb1 mars 2012 · Thymic Stromal Lymphopoietin (TSLP) is an IL-2 cytokine family member secreted by various non-immune cells, such as epithelial cells, smooth muscle cells, fibroblasts, and epidermal... holly ankle bootsWebbThymic stromal lymphopoietin (TSLP) is an IL-7–like cytokine expressed by epithelial cells and keratinocytes. Its receptor comprises TSLP receptor (TSLPR) and IL-7Rα, which is … humbert meats on rapid run in delhiWebbThymic stromal lymphopoietin (TSLP), an interleukin 7-like cytokine, can trigger dendritic cell (DC)-mediated T-helper type 2 (Th2) inflammatory responses. Recent evidence … holly anna ramsay birthdayWebb4 apr. 2024 · Thymic stromal lymphopoietin is a novel proinflammatory mediator in rheumatoid arthritis that potently activates CD1c+ myeloid dendritic cells to attract and … holly and willows pet barn gatlinburg tnWebbResults: The mRNA and protein levels of both March1 and OX40 ligand (OX40L) were increased in the dendritic cells (DCs) from asthmatic children and asthmatic animals. ... 28 Li et al reported that short ragweed pollen could trigger Th2 cells-mediated allergic inflammation through activating thymic stromal lymphopoietin ... humbert meatsWebb10 mars 2024 · Thymic stromal lymphopoietin plays divergent roles in the pathogenesis of atopic and nonatopic asthma phenotypes by either enhancing Th2 responses or curtailing T-helper 17 responses. TSLP signaling in CD41 T cells is required for not only TH2 memory cell formation in vivo but also the recall response of the memory cells to local antigen … hollyannaeree income