Diabetes mellitus is a major contemporary public health challenge.1 According to the US National Diabetes Statistics Report 2024, >30 million Americans (≈9.4% of the population) have diabetes mellitus and an additional 84 million people likely have prediabetes.2 Insulin resistance in peripheral organs as well as … See more The data, analytic methods, and study materials will be or have been made available to other researchers for purposes of reproducing the results or replicating the procedure. Microarray data were deposited in … See more We reveal that bone marrow endothelial cells fuel myelopoiesis under chronic hyperglycemic and inflammatory conditions. We also show that diabetes mellitus activates Egfr signaling in endothelial cells. … See more The authors thank the Massachusetts General Hospital Flow Cytometry Core at the Center for Regenerative Medicine for assistance with fluorescent-assisted cell sorting and Servier … See more
Hematopoiesis and Cardiovascular Disease Circulation Research
WebMay 8, 2024 · Introduction. Hematopoiesis is the process of creating a wide variety of blood and bone marrow cells, namely erythrocytes, platelets, granulocytes, lymphocytes, and monocytes. This process begins with … WebApr 22, 2024 · How bone marrow hematopoiesis contributes to diabetes mellitus complications is incompletely understood. We investigated the role of bone marrow … chemplanner
Frontiers Contribution of Extramedullary Hematopoiesis to ...
WebSep 10, 2024 · Diabetic nephropathy is characterized by damage to both the glomerulus and tubulointerstitium, but relatively little is known about accompanying cell-specific … WebPatients with diabetes mellitus have glycation of various proteins enhanced when compared with non‐diabetic subjects, ... That is to say, it was inferred that patients with … WebNov 1, 2024 · Clonal hematopoiesis in the genome sequencing era. In 2014, three groups examined exome sequencing data from cases and controls within genetic association studies for diabetes, schizophrenia, and solid tumors that together comprised greater than 30,000 persons 26–28.Importantly, these individuals were unselected for hematological … chempionlar ligasi kechagi uchrashular