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Cral-trio domain-containing protein

WebThe CRAL_TRIO protein domain, which is unique to the Sec14 protein superfamily, binds to a diverse set of small lipophilic ligands. Similar domains are found in a range of different proteins including neurofibromatosis type-1, a Ras GTPase-activating Protein (RasGAP) and Rho guanine nucleotide exchange factors (RhoGEFs). WebMutations in another protein containing a CRAL-TRIO domain, alpha-tocopherol transfer protein (TTPA), cause a vitamin E-responsive ataxia. Three-dimensional protein structural modeling predicts that the caytaxin ligand is more polar than vitamin E. Identification of the caytaxin ligand may help develop a therapy for Cayman ataxia.

UniProt

WebCRAL-TRIO domain is a protein structural domain that binds small lipophilic molecules. This domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO … WebNov 1, 2024 · CRAL_TRIO family proteins are cytosolic and contain the SEC14 carboxy-terminal domain [7, 9]. The CRAL_TRIO subgroup derives its name from the cellular … marg and alan\u0027s celebrity weekend https://ewcdma.com

CRAL-TRIO domain - Wikiwand

WebDescription: Homo sapiens motile sperm domain containing 2 (MOSPD2), transcript variant 2, mRNA. ... SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). SIMILARITY: Contains 1 CRAL-TRIO domain. SIMILARITY: Contains 1 MSP domain. Primer design for this transcript WebMay 15, 2010 · The CRAL/TRIO and GOLD domain protein TAP-1 regulates RAF-1 activation Introduction. Cell fates are established during development by spatially … WebApr 21, 2024 · Sec14-like proteins bind PI in a hydrophobic cavity in the CRAL_TRIO domain. In that cavity, another hydrophobic ligand can be bound alternatively. The … kuhnhausen metal concepts

CRAL-TRIO Domain

Category:Molecular evolution and expression of the CRAL_TRIO protein …

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Cral-trio domain-containing protein

CRAL-TRIO Domain

WebSep 11, 2024 · One protein family with membrane recognition and signaling properties is the SEC14-like phosphatidylinositol transfer protein (SEC14L-PITP) superfamily. SEC14L-PITPs, first identified in yeast (Saccharomyces cerevisiae) by screening for secretory mutants, share their characteristic SEC14 domain, also known as CRAL-TRIO domain … WebCRAL/TRIO domain containing protein (AHRD V1 **-- B6U4K1_MAIZE); contains Interpro domain(s) IPR001251 Cellular retinaldehyde-binding/triple function, C-terminal Gene Type protein-coding gene Contig chr06 Last Modified On 01 January 2012 0h00 History. Annotator Top. Name EuGene Automatic Prediction ...

Cral-trio domain-containing protein

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WebCRAL-TRIO domain is a protein structural domain that binds small lipophilic molecules. This domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine exchange factor. ... The N-terminal domain of yeast ECM25 protein has been identified as containing a lipid binding CRAL-TRIO domain. WebCRAL-TRIO domain-containing protein: Unknown: Artifact Q9VCD1-F1: DROME 68.9 Rootletin, isoform D: Unknown: Artifact ... C2 NT-type domain-containing protein: Unknown: Artifact Q8IZT6-F8: HUMAN 64.8 Abnormal spindle-like microcephaly-associated protein: Unknown ...

WebSep 29, 2024 · pfam03765 (PSSM ID: 427494): Conserved Protein Domain Family CRAL_TRIO_N, This all-alpha domain is found to the N-terminus of pfam00650. … WebThe bipartite CRAL_TRIO motif is composed of a large lobe encoding a hydrophobic lipid-binding pocket (CRAL_TRIO_C) that is closed off by a smaller N-terminal lobe (CRAL_TRIO_N) . To analyze the lipid-binding activity of CPSFL1, we used recombinant affinity-purified Sec14 proteins and performed protein−lipid blot overlay assays ( Fig. 5 A ...

WebThe motile sperm domain-containing protein 2 (MSPD2) is found at membrane contact sites of the ER, in which it is anchored by its C-terminal TM helix. It engages lipid … WebDi Mattia et al. (2024) noted that human MOSPD2 is a 518-amino acid protein containing an N-terminal CRAL/TRIO domain, a major sperm protein (MSP) domain, and a potential C-terminal transmembrane domain. A GFP-tagged MOSPD2 was localized to the ER of transfected HeLa cells, and mutation analysis showed that MOSPD2 was anchored to …

WebCRAL_TRIO domain proteins are known to bind small lipophilic molecules such as retinal, inositol and Vitamin E and include such gene family members as PINTA, α-tocopherol …

WebMar 27, 2012 · The CRAL_TRIO protein domain, which is unique to the Sec14 protein superfamily, binds to a diverse set of small lipophilic ligands. Similar domains are found in a range of different proteins including neurofibromatosis type-1, a Ras GTPase-activating Protein (RasGAP) and Rho guanine nucleotide exchange factors (RhoGEFs). Proteins … kuhn\u0027s paradigm theoryWebExplore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest. … kuhner co2 shaking incubatorWeb2.1. 3D modeling and sequence logo of the insect CRAL_TRIO/SEC14 domain The three-dimensional protein structure of the SEC14 domain (containing the CRAL_TRIO domain) was predicted using I-TASSER (Roy et al., 2010), which uses both multiple threading alignments and ab initio modeling with further refinement to obtain the most likely 3D … kuhnhausen\u0027s furniture portland orWebJun 13, 2012 · CRAL-TRIO domain-containing protein. Gene. 100800854. Status. UniProtKB unreviewed (TrEMBL) Organism. Glycine max (Soybean) (Glycine hispida) Amino acids. 286. Protein existence. Predicted. Annotation score. 1/5. Entry. ... SSF52087 CRAL/TRIO domain 1 hit; SSF46938 CRAL/TRIO N-terminal domain 1 hit; MobiDB. marforspace leadershipWebExplore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest. There are 7 hidden Markov models representing the CRAL/TRIO domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match … marg connor napaneeWebSep 29, 2024 · Drawing: All Atoms Virtual Bond. Aligned Rows: up to 5 up to 10 up to 20 up to 40 up to 60 All 95 rows. Download Cn3D. PubMed References. pfam00650 is … marg book careWebCRAL_TRIO domain proteins are known to bind small lipophilic molecules such as retinal, inositol and Vitamin E and include such gene family members as PINTA, α-tocopherol transfer (ATT) proteins, retinoid binding proteins, and clavesins. In insects, very little is known about either the molecular ev … kuhnhausen\u0027s furniture showcase